Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rabl, H; Khoschsorur, G; Hauser, H; Petek, W; Esterbauer, H.
Diminished Production of Malondialdehyde After Carotid-Artery Surgery as a Result of Vitamin Administration
MED SCI RES 1996 24: 777-780.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Hauser Hubert
- Khoschsorur Gholamali
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- Abstract:
- The objective of this study was to establish the antioxidative effect of the vitamins E, C and retinyl palmitate (vitamin A), contained in a multivitamin solution, in carotid artery revascularisation surgery. 57 patients, 67.84 +/- 5.72 years of age, 39 men and 18 women, were divided into a control group (27 subjects) and a group with 30 subjects (mean age 68.46 +/- 5.09 years) who received the vitamin treatment immediately before the start of reperfusion of the brain. The control group (mean age 67.14 +/- 6.37 years) received physiological sodium chloride as placebo. All of the patients suffered from ischaemic cerebrovascular insufficiency manifested as TIA (transitory ischaemic attack) due to haemodynamically significant stenosis of the extracranial part of the ICA (internal carotid artery). Oxidative burst was measured by malondialdehyde (MDA) - thiobarbituric acid reactive substances (TBARS) perioperatively before and 0.5, 1, 2 and 3 h after revascularisation. In the control group MDA-TBARS significantly increased from 0.91 +/- 0.49 to 1.15 +/- 0.41 nmol mL(-1) (p < 0.003) 1 h after reperfusion onset and returned to baseline after 2-3 h. In the vitamin-treated group MDA-TBARS steadily decreased during the reperfusion period (1.11 +/- 0.39, 0.91 +/- 0.42, 0.81 +/- 0.29, 0.78 +/- 0.39, 0.72 +/- 0.24 nmol mL(-1)). The significant difference in MDA-TBARS between control and treatment groups, 1 h after the start at reperfusion was 1.15 +/- 0.41 vs 0.81 +/- 0.29 nmol mL(-1); (p < 0.001). As an indirect parameter of reperfusion injury 13% (4/30 patients) of the patients in the treatment group suffered from headache in contrast to 67% (18/27) in the control group. The perioperative use of antihypertensive drugs was 20% (6/30) in the treatment group, as compared to 78% (21/27) in the control group. These results suggests that vitamin treatment prior to reperfusion might be of beneficial effect, alleviating lipid peroxidation and leading to a better clinical course as regards the central nervous system.
- Find related publications in this database (Keywords)
- Lipid Peroxidation
- Central Nervous System
- Transitory Ischemic Attack
- Malondialdehyde
- Thiobarbituric-Acid-Reactive-Substances
- Antioxidative Vitamin-E
- Vitamin-C
- Vitamin-A
- Carotid Artery Surgery