Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mueller, TF; Raeder, J; Oettl, K; Zitta, S; Klausmann, G; Estelberger, W; Luyckx, VA; Reibnegger, G.
Cystatin C does not detect acute changes in glomerular filtration rate in early diabetic nephropathy.
Ren Fail. 2008; 30(1):21-29
Doi: 10.1080/08860220701741916
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- Co-Autor*innen der Med Uni Graz
- Öttl Karl
- Reibnegger Gilbert
- Zitta Sabine
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- Abstract:
- The measurement of renal functional reserve (acute change in glomerular filtration rate [GFR] after protein load) allows the detection of sub-clinical renal dysfunction and has prognostic implications in diabetes. Our aim was to test cystatin C as an index of GFR and renal functional reserve. GFR was measured by C(Sinistrin) at baseline and after protein load in 28 diabetic patients with serum creatinine <1.2 mg/dL. The C(Sinistrin) was compared with cystatin C, serum creatinine, creatinine clearance, and Cockcroft-Gault formula. Baseline C(Sinistrin) ranged from 67-172 mL/min. Regression analysis showed an overall low relationship between C(Sinistrin) and the indirect markers of GFR. The highest correlation with C(Sinistrin) was obtained for cystatin C clearance (R(2) = 0.58, r = 0.76, p < 0.001), the 1/serum cystatin C (R(2) = 0.58, r = 0.76, p < 0.001), and serum cystatin C (R(2) = 0.52, r = 0.72, p < 0.001). Renal functional reserve was preserved in 6 of 28 patients. There was no significant change in cystatin C in response to protein load. Wide variation in baseline GFR emphasizes the need for the early detection of renal dysfunction. Cystatin C correlated best with C(Sinistrin) at baseline, but did not detect renal functional reserve.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Biological Markers - blood
- Blood Glucose - analysis
- Creatinine - blood Creatinine - urine
- Cystatin C -
- Cystatins - blood
- Diabetic Nephropathies - metabolism Diabetic Nephropathies - physiopathology
- Dietary Proteins - diagnostic use
- Female -
- Glomerular Filtration Rate -
- Humans -
- Kidney Function Tests -
- Male -
- Middle Aged -
- Oligosaccharides - pharmacokinetics
- Find related publications in this database (Keywords)
- creatinine clearance
- cystatin C
- diabetic nephropathy
- glomerular filtration rate
- renal functional reserve