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Selected Publication:
Klugman, KP; Lembeck, F; Markowitz, S; Mitchell, G; Rosendorff, C.
Substance P increases hypothalamic blood flow via an indirect adrenergic-cholinergic interaction.
BRIT J PHARMACOL. 1980; 71(2): 623-629.
Doi: 10.1111/j.1476-5381.1980.tb10982.x
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- Co-authors Med Uni Graz
- Lembeck Fred
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- Abstract:
- 1 Hypothalamic blood flow (HBF) was measured in conscious rabbits by the 133xenon washout technique. 2 Substance P in a dose of 50 or 500 ng increases HBF while 5 ng is without effect. 3 Cholinoceptor blockade, with either atropine or mecamylamine abolishes the vasodilator effect of substance P. 4 Chemical sympathectomy of the hypothalamus with 6-hydroxydopamine, or adrenoceptor blockade with either propranolol or phenoxybenzamine abolishes the effect of substance P on HBF. 5 Destruction of the intracerebral noradrenergic pathway (INP), or blockade of its vasodilator action, with barbiturate or bicarbonate, likewise prevent the vasodilator action of substance P. 6 These results suggest that substance P may cause an increase in HBF via the release of endogenous acetylcholine, which in turn stimulates the INP.
- Find related publications in this database (using NLM MeSH Indexing)
- Acetylcholine - metabolism
- Animals - metabolism
- Female - metabolism
- Hypothalamus - blood supply
- Male - blood supply
- Neural Pathways - drug effects
- Parasympathetic Nervous System - physiology
- Rabbits - physiology
- Receptors, Cholinergic - drug effects
- Regional Blood Flow - drug effects
- Substance P - pharmacology
- Sympathetic Nervous System - physiology
- Vasodilation - drug effects