Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, H; Urban, C; Sovinz, P; Benesch, M; Moser, A; Schwinger, W.
Hemophagocytic lymphohistiocytosis as severe adverse event of antineoplastic treatment in children.
Haematologica. 2008; 93(2): 291-294.
Doi: 10.3324/haematol.11704
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Nebl Andrea Maria
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Hemophagocytic lymphohistiocytosis (HLH) during childhood cancer treatment is a rare adverse event posing major diagnostic and therapeutic challenges. Between 1995 and 2006, 6 children developed HLH while on conventional chemotherapy (n=4) or after allogeneic stem cell transplantation (n=2). Treatment of HLH included dexamethasone and etoposide, 2 children additionally received infliximab or daclizumab. Three children survived, whereas 3 children died 2, 5, and 47 days after diagnosis of HLH. HLH is a severe adverse event of childhood cancer therapy. Early diagnosis and immediate initiation of adequate treatment are mandatory to overcome this severe condition.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Antibodies, Monoclonal - administration and dosage Antibodies, Monoclonal - adverse effects
- Antineoplastic Combined Chemotherapy Protocols - administration and dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Child -
- Dexamethasone - administration and dosage Dexamethasone - adverse effects
- Etoposide - administration and dosage Etoposide - adverse effects
- Female -
- Humans -
- Immunoglobulin G - administration and dosage Immunoglobulin G - adverse effects
- Infant -
- Lymphohistiocytosis, Hemophagocytic - chemically induced Lymphohistiocytosis, Hemophagocytic - diagnosis Lymphohistiocytosis, Hemophagocytic - mortality Lymphohistiocytosis, Hemophagocytic - therapy
- Male -
- Neoplasms - complications Neoplasms - mortality Neoplasms - therapy
- Retrospective Studies -
- Stem Cell Transplantation -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- hemophagocytic lymhohistiocytosis
- children
- malignancy