Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Dahaba, AA; Bornemann, H; Holst, B; Wilfinger, G; Metzler, H.
Comparison of a new neuromuscular transmission monitor compressomyograph with mechanomyograph.
Br J Anaesth. 2008; 100(3): 344-350.
Doi: 10.1093/bja/aem379
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- Co-Autor*innen der Med Uni Graz
- Bornemann-Cimenti Helmar
- Metzler Helfried
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- Abstract:
- BACKGROUND: We developed a new neuromuscular transmission monitor, the compressomyograph (CMG, European patent number: EP 06018557.6, US patent number: US 60/824.541). This is the first preliminary report comparing neuromuscular block monitored by CMG and the Relaxometer mechanomyograph (MMG). METHODS: The two monitors were randomly allocated to the left or right hands of 16 patients. T1, first twitch of the train-of-four (TOF) expressed as percentage of control response, and the TOF ratio (T4:t1) were used to evaluate the neuromuscular block produced by rocuronium 0.6 mg kg(-1). RESULTS: The CMG monitor exhibited no pre-relaxation reverse fade (T4>T1) or T1 exceeding 100%. There was no significant difference in mean (SD) onset time, Dur(25) (time to T1 25% recovery), or Dur(0.9) (time to 0.9 TOF ratio recovery) measured by the CMG [2.4 (0.9), 22.6 (4.1), 43.1 (10.3) min, respectively] compared with MMG [2.1 (0.9), 22.9 (3.3), 43.3 (10.0) min, respectively]. According to Bland and Altman analysis, the bias (upper and lower limits of agreement) for T1% was -0.3% (+13.4% and -13.8%) and for TOF ratio was -0.009 (+0.068 and -0.085). CMG showed 100% sensitivity and 75% specificity in indicating full relaxation for tracheal intubation, and 80% sensitivity with 86% specificity in predicting MMG 0.9 TOF ratio. CONCLUSIONS: The CMG could be a reliable clinical monitor in the daily anaesthesia practice that does not require time to set up or rigid support of the arm.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Androstanols - pharmacology
- Epidemiologic Methods -
- Equipment Design -
- Female -
- Humans -
- Male -
- Middle Aged -
- Monitoring, Intraoperative - instrumentation
- Myography - instrumentation
- Neuromuscular Blockade -
- Neuromuscular Junction - drug effects
- Neuromuscular Nondepolarizing Agents - pharmacology
- Synaptic Transmission - drug effects
- Find related publications in this database (Keywords)
- measurement techniques, neuromuscular block, mechanomyograph
- monitoring
- neuromuscular block, rocuronium