Medizinische Universität Graz - Research portal
Selected Publication:
Popper, H; Pongratz, M; Lanzer, G.
IgA2-alveolitis and eosinophilic pneumonia--a possibly virus-triggered allergy.
ALLERGOL IMMUNOPATHOL. 1982; 10(3): 177-184.
(- Case Report)
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- Leading authors Med Uni Graz
- Popper Helmuth
- Co-authors Med Uni Graz
- Lanzer Gerhard
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- Abstract:
- A case of severe therapy-resistant asthma in a young girl with a duration of two years prior to death is reported. At autopsy antibodies of the IgA2-subtype were demonstrated in the lungs on the alveolar basement membranes. We were able to demonstrate intracellular virus-like structures by electron microscopy; this virus infection is taken to be the cause of antibody production. Following antigen-antibody reaction a non-complement-mediated eosinophilic pneumonia with numerous macrophages developed. This inflammatory reaction showed the injurious effect of eosinophilic granulocytes causing fibrinoid necrosis; this is confirmed by the pronounced depletion of the Charcot-Leyden-granules, equivalent to the release of the major basic protein and the Charcot-Leyden crystal protein. Death was caused by IgA2 deposition in the myocardial vessels with consequent eosinophilic myocarditis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Asthma - etiology
- Female - etiology
- Humans - etiology
- Immunoglobulin A - immunology
- Lung - microbiology
- Myocarditis - etiology
- Pneumonia - etiology
- Pulmonary Alveoli - immunology
- Pulmonary Eosinophilia - etiology
- Virus Diseases - complications
- Viruses - isolation and purification