Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SCHIMPL, G; HOLLWARTH, ME; KHOSCHSORUR, G; SIXTVOIGT, B; MAYR, J; FASCHING, G; HABERLIK, A; STEINWENDER, G; RIEBERER, ML; GOSSLER, R.
EFFECT OF PORTOJUGULAR SHUNT AND ALLOPURINOL ON BACTERIAL TRANSLOCATION INDUCED BY TEMPORARY PORTAL-VEIN OCCLUSION
PEDIAT SURG INT. 1994; 9(4): 254-257.
Doi: 10.1007/BF00832250
Web of Science
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Haberlik Axel
- Khoschsorur Gholamali
- Steinwender Gerhardt
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Bacterial translocation (BT) after ischemia and reperfusion of the gut has been reported. This study was performed to document BT after temporary portal-vein occlusion (PVO) and reperfusion. Male piglets (15 - 20 kg) were assigned to a control group (n = 6), a bio-pump group (n = 6), and an allopurinol group (n = 5). The portal vein was occluded in all animals for 30 min. The control group received no treatment. In the bio-pump group, during PVO a motor-driven portojugular shunt was used. In the allopurinol group, animals received 200 mg/m2 allopurinol IV before PVO. Portal and peripheral venous cultures and mesenteric lymph-node cultures were taken before PVO and after 30 min of reperfusion. Blood samples for determination of malondialdehyde (MDA) were taken before laparotomy, before PVO, and after 5, 25, and 60 min of portal reperfusion. After 30 min of portal reperfusion, in the control group significant BT to the portal vein, peripheral veins, and liver occurred when compared with the bio-pump and allopurinol groups (P <0.05). Allopurinol pretreatment attenuated BT, but was not significant when compared with the control group. MDA, an indicator of oxygen-derived free radical-induced lipid peroxidation, increased significantly in the control and bio-pump groups (P <0.05) after 60 min of portal reperfusion and remained unchanged in the allopurinol group. These data suggest that significant BT and significant generation of oxygen-derived free radicals with subsequent lipid peroxidation occur after temporary PVO and reperfusion. A motor-driven portojugular shunt prevents BT but not be increase of lipid peroxidation. Pretreatment with allopurinol attenuates BT and lipid peroxidation.
- Find related publications in this database (Keywords)
- BACTERIAL TRANSLOCATION
- PORTAL VEIN OCCLUSION
- PORTAL-JUGULAR SHUNT
- ALLOPURINOL