Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Winklhofer-Roob, BM; Ellemunter, H; Frühwirth, M; Schlegel-Haueter, SE; Khoschsorur, G; van't Hof, MA; Shmerling, DH.
Plasma vitamin C concentrations in patients with cystic fibrosis: evidence of associations with lung inflammation.
Am J Clin Nutr. 1997; 65(6): 1858-1866.
Doi: 10.1093/ajcn/65.6.1858
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- Co-Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
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- Abstract:
- Vitamin C status and possible associations with the disease process in cystic fibrosis (CF) patients were investigated. Plasma vitamin C concentrations in patients from two different mid-European populations (Swiss, n = 62; Austrian, n = 60) taking no or low-dose vitamin C from multivitamin supplements did not differ from each other or from control subjects (n = 34). Vitamin C concentrations decreased with age (5.05 mumol.L-1, y-1). When followed up for 12 mo, patients had the highest plasma vitamin C concentrations in February and the lowest in May and August (P < 0.01); the decrease in vitamin C was accompanied by increases in plasma malondialdehyde (P < 0.001) and tumor necrosis factor alpha concentrations (P < 0.01). During supplementation with vitamin E for 2 mo or beta-carotene for 12 mo vitamin C concentrations did not change. They correlated inversely with white blood cell count (r = -0.36, P = 0.008), bands (r = -0.36, P = 0.02), alpha 1-acid glycoprotein (r = -0.45, P = 0.002), interleukin 6 (r = -0.46, P = 0.0006), and neutrophil elastase/alpha 1-proteinase inhibitor complexes (r = -0.34, P = 0.02). In patients with vitamin C concentrations < 40 mumol/L, all indexes of inflammation were relatively high, whereas those with concentrations > 80 mumol/L (upper quartile of control subjects) showed clearly lower values. These results are consistent with the hypothesis that by scavenging oxygen free radicals vitamin C interacts with an inflammation-amplifying cycle of activation of alveolar macrophages and neutrophils, release of proinflammatory cytokines and oxygen free radicals, and inactivation of antiproteases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Ascorbic Acid - blood
- Child - blood
- Child, Preschool - blood
- Cohort Studies - blood
- Cystic Fibrosis - blood
- Cytokines - metabolism
- Dose-Response Relationship, Drug - metabolism
- Female - metabolism
- Humans - metabolism
- Infant - metabolism
- Inflammation - blood
- Interleukin-6 - blood
- Leukocyte Elastase - blood
- Lipid Peroxidation - physiology
- Lung Diseases - blood
- Male - blood
- Malondialdehyde - blood
- Nutritional Status - blood
- Orosomucoid - analysis
- Seasons - analysis
- Tumor Necrosis Factor-alpha - analysis
- Vitamin E - administration and dosage
- beta Carotene - administration and dosage
- Find related publications in this database (Keywords)
- cystic fibrosis
- vitamin C
- inflammation
- free radicals
- cytokines
- malondialdehyde
- neutrophil elastase alpha(1)-proteinase inhibitor complexes
- Shwachman score
- tumor necrosis factor alpha