Medizinische Universität Graz - Research portal
Selected Publication:
Kopera, D; Cerroni, L; Fink-Puches, R; Kerl, H.
Different treatment modalities for the management of a patient with the nevoid basal cell carcinoma syndrome.
J Am Acad Dermatol. 1996; 34(5 Pt 2):937-939
Doi: 10.1016/S0190-9622(96)90085-7
(- Case Report)
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- Leading authors Med Uni Graz
- Kopera Daisy
- Co-authors Med Uni Graz
- Cerroni Lorenzo
- Fink-Puches Regina
- Kerl Helmut
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- Abstract:
- Nevoid basal cell carcinoma (BCC) syndrome is a genetically linked disorder characterized by multiple BCCs associated with various skeletal abnormalities and sometimes with mental retardation. Because of the large number of lesions, treatment of BCCs in these patients may be extremely difficult. The value of different therapeutic options was assessed in a patient with multiple, disfiguring nevoid BCC syndrome. Surgical excision and split-skin grafting was used to remove three larger tumors. Photodynamic therapy led to healing of flat lesions; small papules within the treated areas, however, did not respond to this type of management. Three nodular BCCs treated with intralesional application of interferon alfa-2b were markedly reduced in size. Still, complete healing could not be achieved. Nodular lesions vaporized with the CO2 laser disappeared and showed no recurrence after 2 years of follow up. Our experience indicates that CO2 laser vaporization of BCCs allows the treatment of a large number of lesions in a single session, and is indicated when surgical treatment is not feasible for all lesions. Photodynamic therapy with 5-amino-levulinic acid may be a valid therapeutic option for flat lesions only. Intralesional application of interferon alfa-2b removes papular lesions of small size.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Basal Cell Nevus Syndrome - therapy
- Humans -
- Injections, Intralesional -
- Interferon-alpha - administration & dosage
- Interferon-alpha - therapeutic use
- Laser Therapy -
- Male -
- Photochemotherapy -
- Recombinant Proteins -
- Skin Neoplasms - therapy