Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Halldórsdóttir, AM; Frühwirth, M; Deutsch, A; Aigelsreiter, A; Beham-Schmid, C; Agnarsson, BA; Neumeister, P; Richard Burack, W.
Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma.
Leuk Res. 2008; 32(7): 1015-1021.
Doi: 10.1016/j.leukres.2007.11.028
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Aigelsreiter Ariane
- Beham-Schmid Christine
- Deutsch Alexander
- Frühwirth Margareta
- Neumeister Peter
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- Abstract:
- Somatic hypermutation (SHM) aberrantly targets proto-oncogenes in various non-Hodgkin's lymphoma. To test the association of SHM with transformation of follicular lymphoma (FL), we sequenced mutational hot spots in five proto-oncogenes (BCL6, PAX5, RHOH, MYC and PIM1) in 32 low-grade FL (lgFL) with follicular histology and 26 transformed FL (tFL) with diffuse large cell histology. No difference was detected in the fraction of specimens mutated (75% of lgFL and 77% of tFL) or in the mutation load (0.08 for lgFL vs. 0.06 mutations/100 bp/allele for tFL). Serial specimens were examined from 25 patients showing stable low-grade FL (slgFL; n=6) or a low-grade FL that later transformed into diffuse large cell lymphoma (tFL; n=19). slgFL and tFL patients accumulated similar numbers of mutations in the interval between biopsies. These data indicate that mutations attributable to aberrant SHM occur with similar frequency in low-grade and transformed FL; transformation is not associated with a higher rate of aberrant SHM. Moreover, the frequency of mutations attributable to aberrant SHM in tFL was significantly lower than that reported for de novo diffuse large B cell lymphoma, suggesting differing oncogenic mechanisms in transformed follicular lymphoma and de novo diffuse large B cell lymphoma.
- Find related publications in this database (using NLM MeSH Indexing)
- Cell Transformation, Neoplastic -
- Humans -
- Lymphoma, Follicular - genetics
- Mutation -
- Find related publications in this database (Keywords)
- follicular lymphoma
- somatic hypermutation
- transformation
- diffuse large B cell lymphoma
- BCL6
- MYC
- PAX5
- RHOH
- PIMI