Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gruner, S; Diezel, W; Strunk, D; Zwirner, A; Sönnichsen, N; Anhalt, GJ.
Stimulation of the recruitment of epidermal Langerhans cells by splenopentin.
Arch Dermatol Res. 1990; 281(8): 526-529.
Doi: 10.1007/BF00412738
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- Strunk Dirk
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- Abstract:
- Splenopentin (SP-5: Arg-Lys-Glu-Val-Tyr), a pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin, increases dose-dependently the number of bone marrow colonies (M and GM colonies). Therefore, we tested the stimulatory effect of SP-5 on the recruitment of epidermal Langerhans cells in skin deprived of these cells. A high dose of cyclophosphamide or dexamethasone led to a drastic decrease of LC density in murine skin with slow and incomplete restoration. SP-5 accelerated Langerhans cell recruitment and led to pretreatment levels of Langerhans cell density in the skin. These results indicate that SP-5 may possibly be used to treat disorders (e.g., HIV infection) where impaired Langerhans cell density and function can lead to secondary cutaneous infections.
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- Animals -
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- Mice, Inbred BALB C - drug effects
- Peptide Fragments - pharmacology
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