Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Diezel, W; Gruner, S; Anhalt, GJ; Strunk, D; Shanks, M; Sönnichsen, N.
Contact hypersensitivity (DNCB test) and inhibition by the calcium channel blocker diltiazem
Dermatol Monatsschr. 1989; 175(3): 170-174.
PubMed
- Co-Autor*innen der Med Uni Graz
- Strunk Dirk
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- Abstract:
- We studied the influence of the calcium transport inhibitor diltiazem on epidermal Langerhans cell-induced contact dermatitis against 1-chloro-2.4-dinitrobenzene (DNCB) in Balb/c mice. Diltiazem administered systemically was found to be able to decrease allergic reactions against DNCB. Twenty four hours post challenge animals treated with diltiazem demonstrated a 36% decreased ear swelling compared with non diltiazem-treated animals (p less than 0.001). From these results, we conclude that calcium is important in regulating epidermal Langerhans cell functions and in activating these cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Calcium - metabolism
- Calcium Channels - drug effects
- Dermatitis, Contact - immunology
- Diltiazem - pharmacology
- Dinitrochlorobenzene - immunology
- Mice - immunology
- Mice, Inbred BALB C - immunology
- Skin - immunology