Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
LACKNER, H; URBAN, C; SCHWINGER, W; MANGGE, H; MULLER, W.
CYCLOPHOSPHAMIDE THERAPY IN LIFE-THREATENING INOPERABLE CYSTIC HYGROMAS
PEDIAT SURG INT. 1995; 10(2-3): 199-201.
Doi: 10.1007/BF00171200
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Lackner Herwig
- Co-Autor*innen der Med Uni Graz
- Mangge Harald
- Müller Wilhelm
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Surgical excision is considered the treatment of choice for cystic hygromas (CH). However, radical surgery may result in serious complications, and nerve palsy due to dissection occurs in 12%-33% of cases in most series. Resection is especially difficult and sometimes impossible if the lesion involves the floor of the mouth, tongue, and larynx. Different alternative treatment modalities have been advocated in cases of life-threatening, unresectable CHs, however, most of them are associated with severe side effects and doubtful effectiveness. Two children with inoperable CHs of the head and neck are presented. Since intralesional injection of sclerosing agents was unsuccessful, they were treated with IV cyclophosphamide. In both patients tumor size markedly regressed and vital functions stabilized, even though only partial remission was obtained. Cyclophosphamide seems to be a useful and well-tolerated treatment alternative in children with unresectable life-threatening CHs.
- Find related publications in this database (Keywords)
- CYSTIC HYGROMA
- INOPERABLE
- CYCLOPHOSPHAMIDE