Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reichenberger, F; Voswinckel, R; Enke, B; Rutsch, M; El Fechtali, E; Schmehl, T; Oischewski, H; Schermuly, R; Weissmann, N; Ghofrani, HA; Grimminger, F; Mayer, E; Seeger, W.
Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension.
EUR RESP J. 2007; 30(5): 922-927.
Doi: 10.1183/09031936.00039007
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- Co-Autor*innen der Med Uni Graz
- Olschewski Horst
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- Abstract:
- For chronic thromboembolic pulmonary hypertension not amenable to pulmonary endarterectomy, effective medical therapy is desired. In an open-label uncontrolled clinical trial, 104 patients (mean +/- sem age 62 +/- 11 yrs) with inoperable chronic thromboembolic pulmonary hypertension were treated with 50 mg sildenafil t.i.d. At baseline, patients had severe pulmonary hypertension (pulmonary vascular resistance 863 +/- 38 dyn.s.cm(-5)) and a 6-min walking distance of 310 +/- 11 m. Eight patients were in World Health Organization functional class II, 76 in class III and 20 in class IV. After 3 months' treatment, there was significant haemodynamic improvement, with reduction of pulmonary vascular resistance to 759 +/- 62 dyn.s.cm(-5). The 6-min walking distance increased significantly to 361 +/- 15 m after 3 months' treatment, and to 366 +/- 18 m after 12 months' treatment. A subset of 67 patients received a single dose of 50 mg sildenafil during initial right heart catheterisation. The acute haemodynamic effect of this was not predictive of long-term outcome. In this large series of patients with inoperable chronic thromboembolic pulmonary hypertension, open-label treatment with sildenafil led to significant long-term functional improvement. The acute effect of sildenafil may not predict the long-term outcome of therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Female -
- Heart Catheterization -
- Humans -
- Hypertension, Pulmonary - drug therapy
- Male - drug therapy
- Middle Aged - drug therapy
- Piperazines - therapeutic use
- Purines - therapeutic use
- Statistics, Nonparametric - therapeutic use
- Sulfones - therapeutic use
- Thromboembolism - complications
- Treatment Outcome - complications
- Vascular Resistance - drug effects
- Vasodilator Agents - therapeutic use
- Find related publications in this database (Keywords)
- chronic thromboembolism
- pulmonary hypertension
- sildenafil