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Selected Publication:
Neschen, S; Moore, I; Regittnig, W; Yu, CL; Wang, Y; Pypaert, M; Petersen, KF; Shulman, GI.
Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content.
Am J Physiol Endocrinol Metab. 2002; 282(2): E395-E401.
Doi: 10.1152/ajpendo.00414.2001
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- Co-authors Med Uni Graz
- Regittnig Werner
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- Abstract:
- To examine the mechanism by which fish oil protects against fat-induced insulin resistance, we studied the effects of control, fish oil, and safflower oil diets on peroxisomal content, fatty acyl-CoA, diacylglycerol, and ceramide content in rat liver and muscle. We found that, in contrast to control and safflower oil-fed rats, fish oil feeding induced a 150% increase in the abundance of peroxisomal acyl-CoA oxidase and 3-ketoacyl-CoA thiolase in liver but lacked similar effects in muscle. This was paralleled by an almost twofold increase in hepatic peroxisome content (both P < 0.002 vs. control and safflower). These changes in the fish oil-fed rats were associated with a more than twofold lower hepatic triglyceride/diacylglycerol, as well as intramuscular triglyceride/fatty acyl-CoA, content. In conclusion, these data strongly support the hypothesis that n-3 fatty acids protect against fat-induced insulin resistance by serving as peroxisome proliferator-activated receptor-alpha ligands and thereby induce hepatic, but not intramuscular, peroxisome proliferation. In turn, an increased hepatic beta-oxidative capacity results in lower hepatic triglyceride/diacylglycerol and intramyocellular triglyceride/fatty acyl-CoA content.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Ceramides - metabolism
- Diglycerides - metabolism
- Docosahexaenoic Acids - metabolism
- Eicosapentaenoic Acid - metabolism
- Enzymes - genetics
- Fish Oils - pharmacology
- Lipid Metabolism - pharmacology
- Liver - drug effects
- Male - drug effects
- Mitochondria, Liver - ultrastructure
- Muscle, Skeletal - metabolism
- Oxidation-Reduction - metabolism
- Peroxisomes - metabolism
- RNA, Messenger - metabolism
- Rats - metabolism
- Rats, Sprague-Dawley - metabolism
- Safflower Oil - pharmacology
- Triglycerides - metabolism
- Find related publications in this database (Keywords)
- peroxisome proliferator-activating receptor-alpha
- beta-oxidation
- diacylglycerol
- acyl-CoA oxidase
- 3-ketoacyl-CoA thiolase