Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Lutz, TA; Pieber, TR; Walzer, B; Del Prete, E; Scharrer, E.
Different influence of CGRP (8-37), an amylin and CGRP antagonist, on the anorectic effects of cholecystokinin and bombesin in diabetic and normal rats.
Peptides. 1997; 18(5):643-649
Doi: 10.1016/S0196-9781(97)00124-1
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- Co-Autor*innen der Med Uni Graz
- Pieber Thomas
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- Abstract:
- Because previous studies had suggested that the anorectic effects of cholecystokinin (CCK) and bombesin (BBS) depend partly on the release of amylin or calcitonin gene-related peptide (CGRP), we investigated the influence of the amylin and CGRP receptor antagonist CGRP (8-37) on the anorectic effects of CCK and BBS in streptozotocin (STZ)-diabetic and nondiabetic rats. STZ-diabetic rats had significantly lower plasma amylin and insulin concentrations than nondiabetic control rats. Amylin (5 micrograms/kg or 2.5 micrograms/rat) injected IP at dark onset after 24-h food deprivation elicited an anorectic effect of similar extent in STZ-diabetic and control rats. Under similar conditions, CCK (0.25 and 2 micrograms/kg) and BBS (5 micrograms/kg) reduced food intake in both STZ-diabetic and nondiabetic rats. These effects were markedly attenuated by CGRP (8-37) (10 micrograms/kg) in non-diabetics but not in STZ-diabetic rats. It is concluded that part of the anorectic effects of CCK and BBS depend on the release of amylin from pancreatic B-cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Amyloid - administration and dosage
- Animals - administration and dosage
- Anorexia - chemically induced
- Bombesin - administration and dosage
- Calcitonin Gene-Related Peptide - administration and dosage
- Cholecystokinin - administration and dosage
- Diabetes Mellitus, Experimental - drug therapy
- Drug Combinations - drug therapy
- Eating - drug therapy
- Injections, Intraperitoneal - drug therapy
- Male - drug therapy
- Peptide Fragments - administration and dosage
- Rats - administration and dosage
- Streptozocin - administration and dosage