Medizinische Universität Graz - Research portal
Selected Publication:
Holzer, P; Lembeck, F.
Neurally mediated contraction of ileal longitudinal muscle by substance P.
Neurosci Lett. 1980; 17(1-2):101-105
Doi: 10.1016/0304-3940(80)90069-5
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- Leading authors Med Uni Graz
- Holzer Peter
- Co-authors Med Uni Graz
- Lembeck Fred
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- Abstract:
- The time course of the spasmogenic effect of substance P (SP) on the longitudinal muscle (LM) of the guinea-pig ileum was investigated. Maximum effective concentrations of SP (greater than or equal to 10 ng/ml) produced a fast initial response which subsequently declined to about 50% of the initial contraction. This remaining half-maximum contraction was increased by physostigmine and decreased by tropicamide, morphine, and tetrodotoxin; hexamethonium had no effect. The results indicate that SP, apart from its direct action on the LM, also activates cholinergic neurones innervating the LM.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Cholinergic Fibers - drug effects
- Drug Interactions -
- Female -
- Guinea Pigs -
- Ileum - drug effects
- Male -
- Muscle Contraction - drug effects
- Muscle, Smooth - drug effects
- Neuromuscular Junction - physiology
- Substance P - administration & dosage