Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aberer, E; Brunner, C; Suchanek, G; Klade, H; Barbour, A; Stanek, G; Lassmann, H.
Molecular mimicry and Lyme borreliosis: a shared antigenic determinant between Borrelia burgdorferi and human tissue.
Ann Neurol. 1989; 26(6):732-737
Doi: 10.1002/ana.410260608
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- Führende Autor*innen der Med Uni Graz
- Aberer Elisabeth
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- Abstract:
- The pathogenesis of chronic manifestations in Lyme borreliosis, a disease induced by Borrelia burgdorferi, is at present unresolved. By testing monoclonal antibodies directed against various borrelia antigens, we found an antigenic determinant shared by the 41 kDa flagella protein and human tissue, especially prominent on myelinated fibers of human peripheral nerve, on nerve cells and axons of the central nervous system, as well as on certain epithelial cells (including joint synovia) and on heart muscle cells. Immune reactions against such a shared antigen could play a pathogenetic role in chronic organ manifestations of Lyme borreliosis.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibodies, Monoclonal - immunology
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- Borrelia burgdorferi Group - immunology
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- Humans - immunology
- Lyme Disease - microbiology
- Myelin Sheath - immunology
- Schwann Cells - immunology
- Species Specificity - immunology