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Neumann, R; Pohl-Markl, H; Aberer, E.
Parenteral interferon-alpha treatment of psoriasis.
Dermatologica. 1987; 175(1):23-28 Doi: 10.1159/000248777
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Co-Autor*innen der Med Uni Graz: Aberer Elisabeth
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Abstract:: 12 patients suffering from psoriasis were given recombinant interferon (IFN)-alpha-2c at a daily dosage of 2.5 X 10(6) or 5 X 10(6) IU for up to 4 weeks by the intramuscular route. One patient showed complete regression and remained free of lesions after 12 months of follow-up. Three patients were judged as partial remission with stop of scale formation and flattening of skin lesions. No beneficial effect was seen in 8 patients. Side effects due to IFN-alpha application, such as fever, headache, malaise, and chills disappeared with subsequent treatments. Our findings suggest a possible positive effect of IFN-alpha in psoriasis.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Female -; Humans -; Injections, Intramuscular -; Interferon Type I - adverse effects; Male - adverse effects; Middle Aged - adverse effects; Psoriasis - therapy; Recombinant Proteins - therapeutic use