Medizinische Universität Graz - Research portal
Selected Publication:
Ott, E; Körner, E; Lechner, H.
Hemorheologic treatment of cerebral reversible ischemic episodes with pentoxifylline--a prospective study.
Angiology. 1988; 39(6): 520-525.
Doi: 10.1177/000331978803900605
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- Leading authors Med Uni Graz
- Ott Erwin
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- Abstract:
- One hundred patients (49 males, 51 females) with reversible neurologic deficit due to cerebral ischemia of vascular origin in the carotid artery territory were recruited for a long-term observation to follow up recurrence of ischemic events. Fifty-eight patients (mean age sixty-four years) were treated daily with 1200 mg oral pentoxifylline in addition to basic therapy (antihypertensives, antidiabetic drugs, etc), and 42 matching patients (mean age sixty-two years) of a control group had no pentoxifylline or other hemorheologic medication. The mean observation period was fifty-six months (range thirty-six to sixty). On admission patients presented with increased platelet aggregation and/or impaired red cell filterability and with enhanced red cell aggregation. Five patients in the pentoxifylline group (8.6%) and 16 control patients (38%) suffered a relapse of an ischemic episode. These data support previous reports of a beneficial effect of pentoxifylline in the prevention of cerebral ischemic events.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Blood Circulation -
- Brain Ischemia - blood
- Erythrocyte Deformability - blood
- Female - blood
- Humans - blood
- Male - blood
- Middle Aged - blood
- Pentoxifylline - therapeutic use
- Platelet Aggregation - therapeutic use
- Recurrence - therapeutic use
- Theobromine - analogs and derivatives