Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
ABERER, W; FUCHS, T; PETERS, KP; FROSCH, PJ.
PROPYLENE-GLYCOL - CUTANEOUS SIDE-EFFECTS AND TEST METHODS - LITERATURE AND RESULTS OF A MULTICENTER STUDY OF THE GERMAN CONTACT ALLERGY GROUP (DKG)
DERMATOSEN BERUF UMWELT. 1993; 41(1): 25-27.
Web of Science
- Führende Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- In a multicenter study, it was attempted to determine the ideal test concentration for propylene glycol. Hereby, propylene glycol was tested epicutaneously in concentrations of 5 % in vaseline, 10 %, 30 %, and 50 % in water on 1226 patients. 1 7 % of the patients showed a reaction, of which 94 % were irritative and only 6 % allergic. The clinical relevance of the positive reactions was investigated in usage tests and exact anamnesis. The high epicutaneous test concentrations were proven to be mostly irritative (16 % in Gottingen to 50 % propylene glycol), definite positive reactions were seldom. The usage test supported most of the positive epicutaneous test results, however the clinical relevance could only be determined in two cases. The question as to the best epicutaneous test concentration for propylene glycol could not be clearly determined in a search test. Useful appears the epicutaneous test with 20 % propylene glycol in water. In cases of positive reactions, a control series (100 %, 50 %, 10 % in water) as well as an open usage test in the bend of the elbow with 20 % propylene glycol (in water) should be performed The results must be valued critically in relation to the anamnesis.
- Find related publications in this database (Keywords)
- CONTACT DERMATITIS
- PROPYLENE GLYCOL