Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Stühlinger, W; Innerebner, M; Aberer, W.
The nephrotoxic effect of therapy with fumaric acid esters in psoriasis
Dtsch Med Wochenschr. 1990; 115(45): 1712-1715.
Doi: 10.1055/s-2008-1065215
(- Case Report)
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- Two sisters, aged 25 and 29 years, with generalized psoriasis guttata since childhood, developed nausea, upper-abdominal pain, loss of appetite, palpitations and flushes in the course of local and oral administration of fumaric acid esters. Because of these side effects the treatment was discontinued after about two weeks, and the symptoms disappeared. But proteinuria and haematuria were subsequently noted, creatinine concentration rose to 2.2 and 2.5 mg/dl, respectively, while creatinine clearance fell to 44 and 27 ml/min, respectively. Examination of urinary sediments and analysis of urinary proteins gave results compatible with tubular-interstitial renal damage. The abnormal renal functions and urinary findings proved reversible within three weeks.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Baths -
- Combined Modality Therapy -
- Digestive System - drug effects
- Drug Therapy, Combination - drug effects
- Female - drug effects
- Fumarates - administration and dosage
- Humans - administration and dosage
- Kidney - drug effects
- Kidney Diseases - chemically induced
- Ointments - chemically induced
- Psoriasis - complications
- Time Factors - complications