Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aberer, W; Katz, SI.
Effects of in vivo administration of anti-Ia antibodies on contact sensitivity.
Arch Dermatol. 1989; 125(2): 280-284.
Doi: 10.1001/archderm.125.2.280
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- Führende Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- Our previous studies of the effects of the in vivo administration of anti-la (anti-class II major histocompatibility antigens) antibodies in mice demonstrated that, although the antibodies bind to epidermal Langerhans' cells, they do not affect their antigen-presenting capacity in vitro. In this study we investigated the effects of the in vivo administration of these antibodies on the induction and expression of contact sensitivity. We found that the antibodies inhibit the induction of contact sensitivity significantly and affect the elicitation phase to a much lesser extent. The inhibition is short-lived and probably not attributable to the induction of suppressor cells.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies - immunology
- Dermatitis, Contact - etiology
- Female - etiology
- Histocompatibility Antigens Class II - immunology
- Langerhans Cells - immunology
- Mice - immunology
- Mice, Inbred BALB C - immunology
- Picryl Chloride - immunology
- T-Lymphocytes - immunology
- Time Factors - immunology