Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aberer, W; Groh, V; Bettelheim, P; Radaszkiewicz, T; Wolff, K.
T- and B-cell double lymphoma: immunologic characterization using monoclonal antibodies
Hautarzt. 1988; 39(6): 388-392.
(- Case Report)
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- The coexistence of two non-Hodgkin lymphomas in one patient is extremely rare. We describe a patient who suffered for 17 years from chronic lymphocytic leukemia of B-cell origin with bone marrow and peripheral blood involvement until he developed clinically typical mycosis fungoides of the skin. The neoplastic lymphatic cells in the skin infiltrates were T-cells of the helper/inducer phenotype and thus differed morphologically and by immunological markers from the neoplastic cells in peripheral blood and bone marrow. The clonal B-cell expansion was controlled well over many years by cytotoxic drug therapy, the cutaneous T-cell lymphoma only with limited success by oral photochemotherapy owing to lack of compliance. The patient died 3 years after the diagnosis of MF from a parallel exacerbation of both diseases. Extensive immunohistochemical studies verified the nature of both lymphomas in vivo and at autopsy.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Antibodies, Monoclonal - diagnostic use
- B-Lymphocytes - diagnostic use
- Humans - diagnostic use
- Lymphoma, Non-Hodgkin - diagnosis
- Male - diagnosis
- Neoplasms, Multiple Primary - diagnosis
- T-Lymphocytes - diagnosis