Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aberer, W; Wolff, K.
Scleromyxedema: immunosuppressive therapy with cyclophosphamide
Hautarzt. 1988; 39(5): 277-280.
(- Case Report)
Web of Science
PubMed
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- A 59-year-old male with scleromyxedema showed lichenoid papules over the large joints and buttocks; excessive skin folds, and generalized sclerosis of the skin similar to scleroderma; myopathy and arthritis; cardiovascular and cerebrovascular disease; and an abnormal monoclonal IgG-type protein in the serum. The progression of the disease, lack of established therapeutic modalities and the pronounced systemic involvement in this condition suggested a therapeutic trial employing monthly high-dose i.v. cyclophosphamide pulse therapy, together with low-dose prednisone on alternate days. The results were excellent and both subjective and objective symptoms improved dramatically. Controls performed at regular time intervals during a follow-up period of 12 months have failed to reveal any recurrence of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Cyclophosphamide - administration and dosage
- Drug Therapy, Combination - administration and dosage
- Humans - administration and dosage
- Male - administration and dosage
- Middle Aged - administration and dosage
- Myxedema - complications
- Prednisone - administration and dosage
- Scleroderma, Systemic - complications