Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Schuler, G; Stingl, G; Aberer, W; Stingl-Gazze, LA; Hönigsmann, H; Wolff, K.
Histiocytosis X cells in eosinophilic granuloma express Ia and T6 antigens.
J Invest Dermatol. 1983; 80(5):405-409
Doi: 10.1111/1523-1747.ep12555339
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- Morphologic similarities between histiocytosis X (HX) cells and epidermal Langerhans cells (LC) have led to the hypothesis that HX represents a proliferative disorder of LC. In order to prove the validity of this assumption, we tested single cell suspensions isolated from an eosinophilic granuloma type HX lesion for the presence of various antigenic determinants defined by monoclonal antibodies using an immunoelectron microscopic technique. An anti-Ia reagent reacted with essentially all histiocytic cells and a small portion of lymphocytes whereas plasma cells and eosinophils were negative. T6 antigen, in contrast, was disclosed exclusively on HX cells either with or without Birbeck granules. Pan-T cell-reagent OKT3 reacted only with small lymphocytes. The finding that HX cells from eosinophilic granuloma lesions are the only cells that have the identical surface marker equipment as epidermal LC (Ia antigens, T6 antigen, Fc-IgG, and C3 receptors) strongly supports the concept that these cells are derived from the LC lineage.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Antibodies, Monoclonal - immunology
- Antigens, Surface - immunology
- Eosinophilic Granuloma - immunology
- Female - immunology
- Histiocytosis, Langerhans-Cell - immunology
- Histocompatibility Antigens Class II - immunology
- Humans - immunology
- Langerhans Cells - immunology
- Microscopy, Electron - immunology