Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pratl, B; Benesch, M; Lackner, H; Portugaller, HR; Pusswald, B; Sovinz, P; Schwinger, W; Moser, A; Urban, C.
Partial splenic embolization in children with hereditary spherocytosis.
Eur J Haematol. 2008; 80(1): 76-80.
Doi: 10.1111/j.1600-0609.2007.00979.x
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- Führende Autor*innen der Med Uni Graz
- Pratl Barbara
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Lackner Herwig
- Nebl Andrea Maria
- Portugaller Rupert
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- OBJECTIVES: Although total splenectomy is able to reduce clinical symptoms in patients with hereditary spherocytosis (HS), splenectomized patients are at risk to develop overwhelming bacterial infections and, to a lesser extent, thromboembolic complications. In contrast, partial splenectomy or partial splenic embolization (PSE) may also decrease the rate of hemolytic complications while maintaining residual splenic function. The aim of this study was to investigate the benefit of PSE in children with moderate to severe HS. PATIENTS AND METHODS: We performed PSE via retrograde transfemoral access in eight children (four female, four male) with moderate to severe HS at a median age of 8 yr. HS-related complications before PSE included gallstones in six and aplastic crises in four children. One patient was transfusion-dependent. RESULTS: No acute side effects were seen during or after PSE. Median hemoglobin increased significantly from levels between 7.5 g/dL and 11.65 g/dL before PSE to levels between 8.4 g/dL and 13.35 g/dL after PSE (P = 0.012). Median splenic sizes before PSE ranged from 9.7 cm/m2 to 19.0 cm/m2 and significantly decreased to values between 4.4 cm/m2 and 15.65 cm/m2 during follow-up (P = 0.012). CONCLUSIONS: PSE appears to be a safe, effective and feasible treatment option for the management of children with moderate to severe HS.
- Find related publications in this database (using NLM MeSH Indexing)
- Child -
- Child, Preschool -
- Embolization, Therapeutic - methods
- Female -
- Hematologic Tests -
- Hemoglobins - analysis
- Humans -
- Infant -
- Male -
- Spherocytosis, Hereditary - therapy
- Spleen -
- Splenectomy -
- Find related publications in this database (Keywords)
- partial splenic embolization
- hereditary spherocytosis
- children