Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Weger, W; Hofer, A; Wolf, P; El-Shabrawi, Y; Renner, W; Kerl, H; Salmhofer, W.
The angiotensin-converting enzyme insertion/deletion and the endothelin -134 3A/4A gene polymorphisms in patients with chronic plaque psoriasis.
Exp Dermatol. 2007; 16(12): 993-998.
Doi: 10.1111/j.1600-0625.2007.00620.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Weger Wolfgang
- Co-Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Hofer Angelika
- Kerl Helmut
- Renner Wilfried
- Salmhofer Wolfgang
- Wolf Peter
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- Abstract:
- BACKGROUND: Psoriasis is a common chronic inflammatory skin disease. Vasoactive peptides such as endothelin-1 (ET-1) and bradykinin have previously been implicated in the pathogenesis of chronic plaque psoriasis. The angiotensin-converting enzyme (ACE) gene carries a 287-base pair insertion/deletion (I/D) gene polymorphism, which is associated with plasma concentrations of bradykinin-degrading ACE. A functional polymorphism (EDN1 -134 3A/4A) in the gene encoding ET-1 has been shown to affect ET-1 expression. The purpose of the present study was thus to investigate a hypothesized association between these gene polymorphisms and the presence of chronic plaque psoriasis. METHODS: The present case-control study comprised 207 patients with chronic plaque psoriasis (136 with early onset and 71 with late onset disease) and 182 control subjects. Genotypes of EDN1 and ACE were determined by a 5' exonuclease assay (Taqman). RESULTS: The prevalence of the homozygous ACE II genotype was significantly higher in patients with early-onset psoriasis than among control subjects (30.9% vs 19.2%, P = 0.016), yielding an odds ratio of 1.88 [95% confidence interval (CI): 1.12-3.15] for early-onset disease. For late-onset psoriasis, presence of the ACE II genotype was associated with a non-significant odds ratio 1.54 (95% CI: 0.81-2.92). As for the EDN1 -134 3A/4A gene polymorphism, no significant differences in genotype distributions were found between patients with either early- or late-onset psoriasis and control subjects (EDN1 -134 4A/4A: 9.6% in early-onset and 5.6% late-onset psoriasis vs 7.7% in controls; P > 0.05). CONCLUSIONS: Our data suggest that homozygosity for the ACE I allele may affect susceptibility to early-onset psoriasis.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Aged -
- Austria - epidemiology
- Case-Control Studies - epidemiology
- Endothelin-1 - genetics
- Female - genetics
- Humans - genetics
- INDEL Mutation - genetics
- Male - genetics
- Middle Aged - genetics
- Peptidyl-Dipeptidase A - genetics
- Polymorphism, Genetic - genetics
- Psoriasis - epidemiology
- Find related publications in this database (Keywords)
- ACE
- chronic plaque psoriasis
- endothelin-1
- gene polymorphism
- risk factor