Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Teml, A; Schwab, M; Hommes, DW; Almer, S; Lukas, M; Feichtenschlager, T; Florin, T; Seiderer, J; Petritsch, W; Bokemeyer, B; Kreisel, W; Herrlinger, KR; Knoflach, P; Bonaz, B; Klugmann, T; Herfarth, H; Pedarnig, N; Reinisch, W.
A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease.
WIEN KLIN WOCHENSCHR. 2007; 119(17-18): 519-526.
Doi: 10.1007/s00508-007-0841-0
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Petritsch Wolfgang
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- Abstract:
- Drug-induced liver injury was recently reported as a major complication leading to hepatic nodular regenerative hyperplasia (NRH) in patients with inflammatory bowel disease (IBD) and 6-thioguanine (6-TG) therapy. The aim of the study was to evaluate the prevalence of 6-TG-related hepatotoxicity in a large multi-centered IBD population by means of a systematic online survey. Clinical and laboratory data, imaging techniques (sonography, CT, MRI) and histology of liver biopsies were surveyed in IBD patients treated with 6-TG. The decision on whether liver imaging and/or liver biopsy were performed was exclusively at the discretion of the investigator. 6-TG use was fully documented in 296 patients (median treatment duration 56 weeks, range < 1-207). Laboratory signs of drug-induced liver injury were found in 43 patients (14.5%). Liver imaging revealed pathologic results in 68/176 patients (38.6%). Liver biopsy was performed in a subset of 60 patients; using silver-reticulin staining (n = 59), NRH was considered in 16 patients (27.1%). Age was the only independent, albeit weak, risk factor for development of NRH. This large online survey confirms the strong association between 6-TG treatment and the significant risk of development of NRH in patients with IBD. The definitive diagnosis of NRH depends solely upon liver biopsy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy -
- Child -
- Data Collection -
- Data Interpretation, Statistical -
- Female -
- Focal Nodular Hyperplasia - chemically induced Focal Nodular Hyperplasia - diagnosis Focal Nodular Hyperplasia - pathology Focal Nodular Hyperplasia - ultrasonography
- Humans -
- Inflammatory Bowel Diseases - drug therapy
- Internet -
- Liver - drug effects Liver - pathology
- Magnetic Resonance Imaging -
- Male -
- Middle Aged -
- Questionnaires -
- Risk Factors -
- Smoking -
- Thioguanine - adverse effects
- Treatment Outcome -
- Find related publications in this database (Keywords)
- 6-thioguanine
- drug-induced liver injury
- inflammatory bowel disease
- nodular regenerative hyperplasia
- thiopurines