Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bito, V; Heinzel, FR; Biesmans, L; Antoons, G; Sipido, KR.
Crosstalk between L-type Ca2+ channels and the sarcoplasmic reticulum: alterations during cardiac remodelling.
Cardiovasc Res. 2008; 77(2): 315-324.
Doi: 10.1093/cvr/cvm063
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- Co-Autor*innen der Med Uni Graz
- Antoons Gudrun
- Heinzel Frank
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- Abstract:
- In the cardiac dyad, sarcolemmal L-type Ca(2+) channels (LCCs) and sarcoplasmic reticulum (SR) Ca(2+) release channels (RyR) are structurally in close proximity. This organization provides for an efficient functional coupling, tuning SR Ca(2+) release for optimal contraction of the myocyte. Given that LCC are regulated by the prevailing [Ca(2+)], this structural organization is the setting for feedback mechanisms and crosstalk. A defective coupling of Ca(2+) influx via LCC to activation of RyR has been implicated in reduced SR Ca(2+) release in heart failure. Both functional changes in LCC properties and structural re-organization of LCC in T-tubules could be involved. LCC are regulated by cytosolic Ca(2+), and crosstalk with SR Ca(2+) handling occurs on a long-term basis, i.e. during steady-state changes in heart rate, on an intermediate-term basis, i.e. on a beat-to-beat basis during sudden rate changes, and on a very short- or immediate-term basis, i.e. during a single heartbeat. We review the properties and consequences of these different feedback mechanisms and the changes in heart failure and cardiac hypertrophy that have thus far been studied.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Arrhythmias, Cardiac - etiology
- Calcium - metabolism
- Calcium Channels, L-Type - physiology
- Cardiomegaly - metabolism
- Feedback, Physiological -
- Heart Failure - metabolism
- Heart Rate -
- Humans -
- Myocardial Contraction -
- Ryanodine Receptor Calcium Release Channel - physiology
- Sarcoplasmic Reticulum - physiology
- Find related publications in this database (Keywords)
- cardiac hypertrophy
- heart failure
- calcium channel
- sarcoplasmic reticulum
- excitation-contraction coupling
- arrhythmias