Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schips, L; Lipsky, K; Zigeuner, R; Gidaro, S; Salfellner, M; Rehak, P; Pummer, K; Hubmer, G.
Does overweight impact on the prognosis of patients with renal cell carcinoma? A single center experience of 683 patients.
J SURG ONCOL. 2004; 88(2): 57-61.
Doi: 10.1002/jso.20139
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- Führende Autor*innen der Med Uni Graz
- Schips Luigi
- Zigeuner Richard
- Co-Autor*innen der Med Uni Graz
- Hubmer Gerhart
- Lipsky Katja
- Pummer Karl
- Rehak Peter
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- Abstract:
- An increased incidence of renal cell carcinoma (RCC) in obese patients has been reported by several authors. We investigated the association of body mass index (BMI) with prognosis of patients with RCC. From January 1994 to December 2000, 693 operations for RCC in 683 consecutive patients were performed at our institution. Patients' BMI at operation was evaluated, overall, tumor-specific and progression-free survival was investigated using the Kaplan-Meier method, for multivariate analysis the Cox regression model was used. Four hundred seventeen patients were males, 266 females. Mean age was 62 years (range 16-88). BMI was available in 609 (89.2%). 371/609 (60.9%) of patients exhibited a BMI greater than 25. After a mean follow-up of 41.5 months, 86 (12.6%) patients died from metastatic RCC, and 29 (4.3%) were alive with metastatic disease. A significant advantage regarding overall (P = 0.015) and progression-free (0.017) but not tumor-specific survival (P = 0.057) was found for patients with a BMI of more than 25 compared to normal-weight patients. In multivariate analysis, BMI showed no significant association with tumor-specific survival. Patients with a BMI of more than 25 had a better outcome compared to patients with normal weight in univariate analysis but not multivariate analysis. (c) 2004 Wiley-Liss, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Body Mass Index -
- Carcinoma, Renal Cell - epidemiology
- Disease-Free Survival - epidemiology
- Female - epidemiology
- Humans - epidemiology
- Incidence - epidemiology
- Kidney Neoplasms - epidemiology
- Male - epidemiology
- Middle Aged - epidemiology
- Multivariate Analysis - epidemiology
- Obesity - epidemiology
- Prognosis - epidemiology
- Proportional Hazards Models - epidemiology
- Survival Rate - epidemiology
- Find related publications in this database (Keywords)
- body mass index
- kidney
- cancer
- metastatic disease
- Cox regression
- outcome