Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sundl, I; Guardiola, M; Khoschsorur, G; Solà, R; Vallvé, JC; Godàs, G; Masana, L; Maritschnegg, M; Meinitzer, A; Cardinault, N; Roob, JM; Rock, E; Winklhofer-Roob, BM; Ribalta, J.
Increased concentrations of circulating vitamin E in carriers of the apolipoprotein A5 gene - 1131T>C variant and associations with plasma lipids and lipid peroxidation.
J LIPID RES. 2007; 48(11): 2506-2513.
Doi: 10.1194/jlr.M700285-JLR200
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- Co-Autor*innen der Med Uni Graz
- Khoschsorur Gholamali
- Meinitzer Andreas
- Roob Johannes
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- Abstract:
- The aim of this study was to investigate the effects of the apolipoprotein A5 (APOA5) 1131T>C gene variant on vitamin E status and lipid profile. The gene variant was determined in 297 healthy nonsmoking men aged 20-75 years and recruited in the VITAGE Project. Effects of the genotype on vitamin E in plasma, LDL, and buccal mucosa cells (BMC) as well as on cholesterol and triglyceride (TG) concentrations in plasma and apolipoprotein A-I (apoA-I), apoB, apoE, apoC-III, and plasma fatty acids were determined. Plasma malondialdehyde concentrations as a marker of in vivo lipid peroxidation were determined. C allele carriers showed significantly higher TG, VLDL, and LDL in plasma, higher cholesterol in VLDL and intermediate density lipoprotein, and higher plasma fatty acids. Plasma alpha-tocopherol (but not gamma-tocopherol, LDL alpha- and gamma-tocopherol, or BMC total vitamin E) was increased significantly in C allele carriers compared with homozygote T allele carriers (P = 0.02), but not after adjustment for cholesterol or TG. Plasma malondialdehyde concentrations did not differ between genotypes. In conclusion, higher plasma lipids in the TC+CC genotype are efficiently protected against lipid peroxidation by higher alpha-tocopherol concentrations. Lipid-standardized vitamin E should be used to reliably assess vitamin E status in genetic association studies.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Apolipoproteins A - genetics
- Cross-Sectional Studies - genetics
- Dietary Fats - administration and dosage
- Fatty Acids - blood
- Humans - blood
- Lipid Peroxidation - blood
- Lipids - blood
- Male - blood
- Malondialdehyde - blood
- Middle Aged - blood
- Polymorphism, Genetic - blood
- Vitamin E - blood
- Find related publications in this database (Keywords)
- polymorphism
- single nucleotide polymorphism
- alpha-tocopherol
- gamma-tocopherol
- triglycerides
- cholesterol
- plasma fatty acids
- lipoproteins