Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hauer, AC; Finn, TM; MacDonald, TT; Spencer, J; Isaacson, PG.
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
J Clin Pathol. 1997; 50(11):957-959
Doi: 10.1136/jcp.50.11.957
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- Führende Autor*innen der Med Uni Graz
- Hauer Almuthe
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- Abstract:
- Previous studies have suggested that the dependence of low grade B cell gastric lymphoma on infection of the gastric mucosa with Helicobacter pylori results from help provided by H pylori specific tumour infiltrating T cells. ELISPOT analysis was used to characterise functional subpopulations of tumour infiltrating T cells. The production of the TH1 cytokine interferon gamma and TH2 cytokines interleukin (IL)-4, IL-5, and IL-10 were measured in tumour cell suspensions from two cases of low grade B cell gastric lymphoma, one case of thyroid gland lymphoma, and one case of salivary gland lymphoma. Cells were assayed on day 0 and following 24 hours incubation either in culture medium or with a range of strains of H pylori. There was a dominant TH1-type (pro-inflammatory) response consistent with the TH1 response observed in H pylori gastritis.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, Bacterial - immunology
- Cytokines - biosynthesis
- Helicobacter pylori - immunology
- Humans - immunology
- Interferon Type II - biosynthesis
- Interleukins - biosynthesis
- Lymphoma, B-Cell, Marginal Zone - immunology
- Neoplasm Proteins - biosynthesis
- Stomach Neoplasms - immunology
- Th1 Cells - immunology
- Th2 Cells - immunology
- Tumor Cells, Cultured - immunology
- Find related publications in this database (Keywords)
- stomach
- lymphoma
- Helicobacter pylori
- cytokines