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Stranzl, H; Peintinger, F; Ofner, P; Prettenhofer, U; Mayer, R; Hackl, A.
Regional nodal recurrence in the management of breast cancer patients with one to three positive axillary lymph nodes. Outcome of patients following tangential irradiation without a separate nodal field.
Strahlenther Onkol. 2004; 180(10):623-628 Doi: 10.1007/s00066-004-1241-2
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Führende Autor*innen der Med Uni Graz
Stranzl-Lawatsch Heidi
Co-Autor*innen der Med Uni Graz
Hackl Arnulf
Mayer Ramona
Ofner-Kopeinig Petra
Peintinger Florentia
Prettenhofer Ulrike
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Abstract:
Purpose: To exam in e the prognosis of breast cancer patients (T1-3, one to three positive axillary Lymph nodes) and Loco regional failure rate after breast-conserving therapy/modified radical mastectomy and adequate axillary dissection following tangential radiotherapy without irradiation of the regional lymph nodes. Patients and Methods: From 1994 to 2002, the medical records of 183 breast cancer patients (T1-3, one to three involved axillary lymph nodes) were examined in order to identify those experiencing regional nodal recurrence, with or without Local recurrence. The median age of the patient population was 58 years (range, 28-86 years). All patients underwent surgical treatment, either breast-conserving therapy (n = 146) or modified radical mastectomy (n = 37). The median number of Lymph nodes removed was twelve (range, seven to 26 nodes). Irradiation was given to the breast through tangential fields. Chemotherapy was administered to 101 patients (55%), hormonal therapy to 124 (60%), and combined systemic treatment to 47 (26%). Results: The median observation time was 44.4 months (range, 11-102 months). Of the 14 patients (7.7%) with a relapse, six (3.3%) had a Local recurrence, five (2.8%) a regional relapse, and three (1.6%) a simultaneous recurrence. Nine out of 14 patients with locoregional relapse developed distant failure subsequently and seven of them (78%) died of the disease. Conclusion: Regional recurrence is uncommon among patients with one to three positive axillary Lymph nodes treated with surgery, adequate axillary dissection, and tangential field irradiation only. The authors conclude that regional nodal irradiation should not routinely be given following adequate axillary dissection when only one to three Lymph nodes are positive.
Find related publications in this database (using NLM MeSH Indexing)
Adult -
Aged -
Aged, 80 and over -
Aged, 80 and over - epidemiology
Axilla -
Breast Neoplasms - mortality Breast Neoplasms - therapy
Female -
Humans -
Incidence -
Lymphatic Metastasis -
Mastectomy - statistics & numerical data
Middle Aged -
Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - therapy
Prevalence -
Prognosis -
Radiotherapy - statistics & numerical data
Retrospective Studies -
Risk Assessment - methods
Risk Factors -
Survival Analysis -
Treatment Outcome -

Find related publications in this database (Keywords)
breast cancer
adjuvant irradiation
one to three positive lymph nodes
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