Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Reinisch, W; Dejaco, C; Knoflach, P; Petritsch, W; Vogelsang, H; Tilg, H.
Immunosuppressive therapy for inflammatory bowel disease: consensus by the Austrian working group on IBD.
Z GASTROENTEROL. 2004; 42(9): 1033-1045.
Doi: 10.1055/s-2004-813500
Web of Science
PubMed
FullText
FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Petritsch Wolfgang
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Azathioprine (AZA) or 6-mercaptopurine (6-MP) are the immunosuppressive drugs of choice in the treatment of inflammatory bowel disorders (IBD). Optimal dosage for AZA is around 2.5 mg/kg body weight and induction of remission by these drugs may take 6 - 7 months. Intramuscularly applied Methotrexate (MTX) is the second choice, while its efficacy starts earlier than that of AZA; studies assessing oral low-dose MTX treatment are lacking. Cyclosporin is the standard treatment in case of steroid-refractory severe ulcerative colitis. This drug may also be used in patients with severe extraintestinal manifestations of IBD. Regarding other immunosuppressive drugs such as mycophenolic acid or 6-thioguanine respective controlled clinical study data are not available. The risk of malignancy using immunosuppressive drugs such as AZA is low and furthermore, especially AZA and 6-MP can be used rather safely during pregnancy.
- Find related publications in this database (using NLM MeSH Indexing)
- 6-Mercaptopurine - administration and dosage 6-Mercaptopurine - therapeutic use
- Administration, Oral -
- Azathioprine - administration and dosage Azathioprine - therapeutic use
- Colitis, Ulcerative - drug therapy
- Crohn Disease - drug therapy
- Cyclosporine - administration and dosage Cyclosporine - therapeutic use
- Female -
- Follow-Up Studies -
- Humans -
- Immunosuppressive Agents - administration and dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use
- Inflammatory Bowel Diseases - drug therapy
- Injections, Intramuscular -
- Male -
- Methotrexate - administration and dosage Methotrexate - therapeutic use
- Placebos -
- Pregnancy -
- Randomized Controlled Trials as Topic -
- Remission Induction -
- Retrospective Studies -
- Safety -
- Time Factors -