Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Resch, B; Gallistl, S; Kutschera, J; Mannhalter, C; Muntean, W; Mueller, WD.
Thrombophilic polymorphisms--factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations--and preterm birth.
WIEN KLIN WOCHENSCHR. 2004; 116(17-18): 622-626.
Doi: 10.1007/s00508-004-0223-9
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Resch Bernhard
- Co-Autor*innen der Med Uni Graz
- Gallistl Siegfried
- Müller Wilhelm
- Muntean Eugen
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- Abstract:
- AIM OF THE STUDY: To evaluate the influence of three common thrombophilic polymorphisms, factor V Leiden (FV), prothrombin G20210A (PT), and methylenetetrahydrofolate reductase (MTHFR) C677T mutations, on preterm birth of unknown cause. PATIENTS AND METHODS: A single-centre case-control study of women with preterm infants < or =35 weeks of gestation, in whom obvious maternal, uterine, and fetal causes responsible for preterm birth were excluded (n = 35). The controls were 54 women with term infants hospitalised in the same ward. RESULTS: There were no significant differences between the groups of mothers in history of fetal loss, venous or familial thrombosis, or previous preterm birth. FV was found in 8.6% of the cases, PT in 5.7%, and MTHFR mutation (homozygous) in 4.8% compared with 5.4% (p=0.292, OR 1.594, CI95% 0.303-8.384), 7.4% (p=0.379, OR 0.758, CI95% 0.131-4.374), and 4.5% (p = 0.485, OR 1.050, CI95% 0.090-12.276), respectively, in the controls. Differences in the three thrombophilic polymorphisms in the two groups of infants were also not significant. CONCLUSION: We could not demonstrate a distinct association between these thrombophilic polymorphisms and preterm birth.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Case-Control Studies -
- Factor V - genetics
- Female - genetics
- Gestational Age - genetics
- Heterozygote - genetics
- Homozygote - genetics
- Humans - genetics
- Infant, Newborn - genetics
- Maternal Age - genetics
- Methylenetetrahydrofolate Reductase (NADPH2) - genetics
- Mutation - genetics
- Odds Ratio - genetics
- Polymorphism, Genetic - genetics
- Pregnancy - genetics
- Premature Birth - genetics
- Prothrombin - genetics
- Thrombophilia - genetics
- Find related publications in this database (Keywords)
- factor V Leiden
- methylenetetrahydrofolate reductase C677T mutation
- preterm birth
- prothrombin G20210A variant