Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bakris, GL; Ruilope, L; Locatelli, F; Ptaszynska, A; Pieske, B; de Champlain, J; Weber, MA; Raz, I.
Treatment of microalbuminuria in hypertensive subjects with elevated cardiovascular risk: Results of the IMPROVE trial
KIDNEY INT. 2007; 72(7): 879-885.
Doi: 10.1038/sj.ki.5002455
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- Co-Autor*innen der Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- Microalbuminuria independently predicts increased cardiovascular risk in hypertensive patients, especially in those with concomitant diabetes or established cardiovascular disease. Drugs that target the renin-angiotensin-aldosterone system reduce microalbuminuria regardless of diabetic status. The Irbesartan in the Management of PROteinuric patients at high risk for Vascular Events was a multicenter, randomized, double-blind, placebo-controlled paralleled group study in which hypertensive patients with microalbuminuria and increased cardiovascular risk were randomized to 20 weeks treatment with ramipril plus irbesartan or to ramipril plus placebo. Patients discontinued or tapered previous antihypertensive therapy during a 14-day placebo lead-in period. Change in albumin excretion rate from baseline to week 20 was the primary end point. Adjusted week 20 baseline geometric ratios for ramipril plus irbesartan and ramipril plus placebo were not significantly different. Although differences in blood pressure reductions were observed between the two treatments, these changes did not affect microalbuminuria. More patients on dual therapy achieved target blood pressure goals at week 20 than with monotherapy. The incidence of adverse effects and treatment-related adverse effects was similar in both groups. Our results suggest that patients with cardiovascular risk and relatively low albumin excretion rates in early-stage disease may only require monotherapy with renin-angiotensin-aldosterone blocking agents.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Albuminuria - complications Albuminuria - drug therapy
- Angiotensin II Type 1 Receptor Blockers - adverse effects Angiotensin II Type 1 Receptor Blockers - therapeutic use
- Angiotensin-Converting Enzyme Inhibitors - adverse effects Angiotensin-Converting Enzyme Inhibitors - therapeutic use
- Biphenyl Compounds - adverse effects Biphenyl Compounds - therapeutic use
- Cardiovascular Diseases - prevention and control
- Female -
- Humans -
- Hypertension - complications
- Male -
- Middle Aged -
- Ramipril - adverse effects Ramipril - therapeutic use
- Tetrazoles - adverse effects Tetrazoles - therapeutic use
- Treatment Outcome -
- Find related publications in this database (Keywords)
- angiotensin-converting enzyme inhibitor
- angiotensin II receptor blocker
- hypertension
- microalbuminuria
- proteinuria
- renoprotection