Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
El-Shabrawi, Y; Walch, A; Hermann, J; Egger, G; Foster, CS.
Inhibition of MMP-dependent chemotaxis and amelioration of experimental autoimmune uveitis with a selective metalloproteinase-2 and -9 inhibitor.
J Neuroimmunol. 2004; 155(1-2):13-20
Doi: 10.1016/j.jneuroim.2004.05.010
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- El-Shabrawi Yosuf
- Co-Autor*innen der Med Uni Graz
- Egger Gerd
- Hermann Josef
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- Abstract:
- The chemotaxis of inflammatory cells depends on proteolytic disruption of extracellular matrix components. The metalloproteinases (MMP)-2 and -9 enable T-lymphocytes to pass through basement membranes. Selective inhibition of only MMP-2 and -9 almost completely abolished the ability of lymphocytes to digest collagen. The chemotaxis of lymphocytes was reduced 40%. In our in-vivo model of experimental autoimmune uveitis (EAU), 46% of the animals in the treated group remained disease-free, whereas all animals in the control group developed EAU. The mean activity of the disease was also statistically significantly reduced. The data suggest that selective MMP-2 and -9 inhibition might be a treatment option.
- Find related publications in this database (using NLM MeSH Indexing)
- Amino Acid Motifs - immunology
- Animals - immunology
- Autoimmune Diseases - drug therapy
- Basement Membrane - drug effects
- Biological Markers - drug effects
- Chemotaxis, Leukocyte - drug effects
- Disease Models, Animal - drug effects
- Down-Regulation - drug effects
- Enzyme Inhibitors - pharmacology
- Extracellular Matrix - drug effects
- Female - drug effects
- Macrophages - drug effects
- Matrix Metalloproteinase 2 - antagonists and inhibitors
- Matrix Metalloproteinase 9 - antagonists and inhibitors
- Mice - antagonists and inhibitors
- Monocytes - drug effects
- Peptide Fragments - pharmacology
- Retina - pathology
- T-Lymphocytes - drug effects
- Treatment Outcome - drug effects
- Uveitis - drug therapy
- Find related publications in this database (Keywords)
- rodent
- T-lymphocytes
- autoimmunity
- cell trafficking
- EAU
- MMP
- uveitis