Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Peskar, BM; Wong, HC; Walsh, JH; Holzer, P.
A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection.
EUR J PHARMACOL 1993 250: 201-203.
Doi: 10.1016%2F0014-2999%2893%2990645-X
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- Co-Autor*innen der Med Uni Graz
- Holzer Peter
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- Abstract:
- Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin. This experimental paradigm was used to prove the effectiveness of a monoclonal anti-CGRP antibody. The experiments were performed in anaesthetized rats in which intragastric capsaicin (0.5 mg/kg) reduced gastric injury due to ethanol (50%) by 72%. The protective effect of capsaicin was abolished by close arterial administration of the anti-CGRP antibody #4901 (5 mg) to the stomach. A monoclonal antibody to keyhole limpet haemocyanin was without effect. These data establish anti-CGRP antibody #4901 as a tool to neutralize endogenously released CGRP and show that CGRP is indispensable for the gastroprotective action of capsaicin.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antibodies, Monoclonal - physiology
- Calcitonin Gene-Related Peptide - immunology
- Capsaicin - pharmacology
- Ethanol - toxicity
- Gastric Mucosa - drug effects
- Hemocyanin - immunology
- Injections, Intra-Arterial - immunology
- Male - immunology
- Rats - immunology
- Rats, Wistar - immunology
- Research Support, Non-U.S. Gov't - immunology
- Research Support, U.S. Gov't, P.H.S. - immunology
- Find related publications in this database (Keywords)
- Capsaicin
- CGRP (Calcitonin Gene-Related Peptide)
- Monoclonal Anti-CGRP Antibody
- Immuno-Neutralization
- Gastric Mucosa
- Gastric Mucosal Protection
- Gastric Mucosal Injury