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SHR Neuro Cancer Cardio Lipid Metab Microb
Streubel, B; Simonitsch-Klupp, I; Müllauer, L; Lamprecht, A; Huber, D; Siebert, R; Stolte, M; Trautinger, F; Lukas, J; Püspök, A; Formanek, M; Assanasen, T; Müller-Hermelink, HK; Cerroni, L; Raderer, M; Chott, A.
Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites.
LEUKEMIA. 2004; 18(10): 1722-1726.
Doi: 10.1038/sj.leu.2403501
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- Co-authors Med Uni Graz
- Cerroni Lorenzo
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- Abstract:
- Although several recurrent genetic aberrations are known to occur in MALT lymphoma, no comprehensive study on the most prevalent MALT lymphoma-associated genetic aberrations is available. We therefore screened 252 primary MALT lymphomas for translocations t(11;18)(q21;q21), t(14;18)(q32;q21), and t(1;14)(p22;q32), and trisomies 3 and 18. The above-listed translocations occurred mutually exclusively and were detected overall in 13.5, 10.8, and 1.6% of the cases; trisomy 3 and/or 18 occurred in 42.1%. The frequency at which the translocations occurred varied markedly with the primary site of disease. The t(11;18)(q21;q21) was mainly detected in pulmonary and gastric tumors, whereas the t(14;18)(q32;q21) was most commonly found in lesions of the ocular adnexa/orbit, skin, and salivary glands. Trisomies 3 and 18 each occurred most frequently in intestinal and salivary gland MALT lymphomas. Our results demonstrate that the three translocations and trisomies 3 and 18 occur at markedly variable frequencies in MALT lymphoma of different sites.
- Find related publications in this database (using NLM MeSH Indexing)
- Chromosome Aberrations -
- Chromosomes, Human, Pair 11 - genetics
- Chromosomes, Human, Pair 14 - genetics
- Chromosomes, Human, Pair 18 - genetics
- Chromosomes, Human, Pair 3 - genetics
- Gene Frequency - genetics
- Humans - genetics
- In Situ Hybridization, Fluorescence - genetics
- Lymphoma, Mucosa-Associated Lymphoid Tissue - classification
- Organ Specificity - classification
- Translocation, Genetic - classification
- Trisomy - genetics
- Variation (Genetics) - genetics
- Find related publications in this database (Keywords)
- MALT lymphoma
- genetics
- MALT1
- API2
- BCL10