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Schwinger, RH; Böhm, M; Pieske, B; Erdmann, E.
Different beta-adrenoceptor-effector coupling in human ventricular and atrial myocardium.
Eur J Clin Invest. 1991; 21(4): 443-451.
Doi: 10.1111/j.1365-2362.1991.tb01393.x
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- Co-authors Med Uni Graz
- Pieske Burkert Mathias
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- Abstract:
- To examine whether the downregulation of beta-adrenoceptors is accompanied by reduced beta-adrenoceptor-mediated effects in atrial as well as in ventricular myocardium, we investigated the beta-adrenoceptor-effector coupling in atrial and papillary muscle strips from patients with terminal heart failure (heart transplantation because of dilated cardiomyopathy; New York Heart Association Class IV, NYHA IV) and moderate heart failure (mitral valve replacement, NYHA II-III) and in tissue from non-failing hearts. The isometric force of contraction induced by isoprenaline (0.001-1 mumoll-1) or Ca2+ (1.8-15 mmoll-1) in atrial muscle strips and papillary muscle strips has been measured. We also examined the number of beta-adrenoceptors in both tissues by radioligand binding. The degree of heart failure affected neither the potency (EC50: control: 0.01 (0.001-0.082) mumoll-1; NYHA II-III: 0.01 (0.001-0.125) mumoll-1; NYHA IV: 0.01 (0.001-0.160) mumoll-1) nor the efficacy (NYHA IV: 7.8 +/- 1.0 mN; NYHA II-III: 6.1 +/- 0.7 mN; control: 7.7 +/- 0.9 mN) of the isoprenaline-mediated increase in force of contraction in atrial muscle strips. This is in spite of a reduced number of beta-adrenoceptors in moderately (NYHA II-III) and terminally (NYHA IV) failing atrial myocardium compared to non-failing atrial myocardium (P less than 0.05). In contrast, in papillary muscle strips increasing degrees of heart failure were accompanied by a progressive reduction of the isoprenaline-mediated increase in force of contraction (P less than 0.05) as well as by a progressive decrease of beta-adrenoceptors (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cardiomyopathy, Dilated - metabolism
- Female - metabolism
- Heart Atria - metabolism
- Heart Failure, Congestive - metabolism
- Heart Ventricles - metabolism
- Humans - metabolism
- Isoproterenol - pharmacology
- Male - pharmacology
- Middle Aged - pharmacology
- Myocardial Contraction - drug effects
- Myocardium - metabolism
- Papillary Muscles - metabolism
- Receptors, Adrenergic, beta - metabolism
- Find related publications in this database (Keywords)
- BETA-ADRENOCEPTOR
- DILATED CARDIOMYOPATHY
- HEART FAILURE
- HUMAN MYOCARDIUM
- LEFT VENTRICULAR MYOCARDIUM
- RIGHT ATRIAL MYOCARDIUM
- SPARE RECEPTOR