Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Öttl, K; Greilberger, J; Reibnegger, G.
Modulation of free radical formation by pterin derivatives
PTERIDINES. 2004; 15: 97-101.
Doi: 10.1515/pteridines.2004.15.3.97
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Öttl Karl
- Co-Autor*innen der Med Uni Graz
- Greilberger Joachim
- Reibnegger Gilbert
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- Abstract:
- All classes of pterins, fully reduced tetrahydropterins, aromatic pterins and dihydropterins have been investigated upon their effects on radical mediated reactions. Meanwhile all these classes were shown to act as both, pro- and antioxidants by a number of different methods including chemical, biochemical and biological systems. From reduced pterins radicals including oxygen-, nitrogen- and pterin-radicals are formed enzymatically and non-enzymatically, reduced pterins react with free radicals and serve as reductive agents. All classes of pterins may interfere with enzymes involved in radical formation. Upon the diversity of possibilities the net effect of a particular compound is a question of the experimental settings and the physiological relevant role often remains obscure.
- Find related publications in this database (Keywords)
- pterin
- free radical
- antioxidant
- oxidative stress