Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stanzer, S; Dandachi, N; Balic, M; Resel, M; Samonigg, H; Bauernhofer, T.
Resistance to apoptosis and expansion of regulatory T cells in relation to the detection of circulating tumor cells in patients with metastatic epithelial cancer.
J Clin Immunol. 2008; 28(2):107-114
Doi: 10.1007/s10875-007-9139-2
Web of Science
PubMed
FullText
FullText_MUG
Google Scholar
- Führende Autor*innen der Med Uni Graz
- Stanzer Stefanie
- Co-Autor*innen der Med Uni Graz
- Balic Marija
- Bauernhofer Thomas
- Dandachi Nadia
- Resel Margit
- Samonigg Hellmut
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Regulatory T cells may be crucial in the development of T cell tolerance to malignancies and contribute to immune dysfunctions. We investigated the percentage, activity, and onset of apoptosis of T cell subpopulations by multicolor flow cytometry in metastatic epithelial cancer patients compared to normal controls. Furthermore, a possible relationship between the presence of circulating tumor cells detected by immunocytochemistry and immune cell abnormalities was evaluated. Our study demonstrated a significantly elevated proportion of regulatory T cells in cancer patients (p < 0.001). In contrast to all other T cell subpopulations, regulatory T cells showed comparable Annexin V-binding characteristics in patients and normal controls. No relationship between the detection of circulating tumor cells and immune dysfunction was observed. These results indicate that cancer patients have a higher number of regulatory T cells with resistance to apoptotic stimuli partly responsible for immune dysfunctions as often observed in cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Annexin A5 - chemistry
- Antigens, CD - metabolism
- Antigens, CD95 - metabolism
- Apoptosis - immunology
- CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism
- CTLA-4 Antigen -
- Carcinoma - blood Carcinoma - immunology Carcinoma - pathology
- Female -
- Humans -
- Interleukin-2 Receptor alpha Subunit - analysis
- Lymphocyte Count -
- Male -
- Middle Aged -
- Neoplasm Metastasis -
- T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism
- T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
- Find related publications in this database (Keywords)
- regulatory T cells
- apoptosis
- CTLA4
- circulating tumor cells
- immune dysfunctions
- epithelial cancer