Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
El Shabrawi-Caelen, L; Kerl, H; Cerroni, L.
Melan-A: not a helpful marker in distinction between melanoma in situ on sun-damaged skin and pigmented actinic keratosis.
AMER J DERMATOPATHOL. 2004; 26(5): 364-366.
Doi: 10.1097%2F00000372-200410000-00003
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- Führende Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- El-Shabrawi-Caelen Laila
- Co-Autor*innen der Med Uni Graz
- Kerl Helmut
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- Abstract:
- Pigmented actinic keratosis is one of the simulators of early melanoma in situ from severely sun-damaged skin. Close scrutiny of the hematoxylin and eosin stained section does not always allow an unequivocal diagnosis, because it is sometimes difficult to distinguish pigmented keratinocytes from melanocytes. Immunohistochemical stains, such as S-100 and HMB-45, are used routinely to address this problem. Melan-A, also known as MART-1, is an additional melanocytic marker and has proved to be useful in identifying metastatic tumors of melanocytic origin. The usefulness of this marker to discriminate pigmented actinic keratosis from early melanoma in situ, however, has not yet been a subject of investigation. In this study we evaluated Melan-A expression in ten unequivocal cases of pigmented actinic keratosis and compared the staining pattern with that of S-100, HMB-45, and tyrosinase. In all ten cases the number of cells highlighted with Melan-A was by far larger than those labeled with S-100, HMB-45, and tyrosinase. Four cases showed clusters of Melan-A positive cells being suggestive of melanocytic nests. Even areas of normal skin adjacent to the actinic keratosis featured prominent staining of Melan-A, but only inconsistent labeling of intraepidermal melanocytes with S-100, HMB-45, and tyrosinase. We therefore believe that Melan-A is a more sensitive marker for intraepidermal melanocytes than S-100, HMB-45, and tyrosinase. In addition there may be expression of Melan-A in keratinocytes and nonmelanocytic cells. To avoid an erroneous diagnosis of malignant melanoma one should therefore interpret results obtained from Melan-A stained slides carefully and in the context with other melanocytic markers.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Antigens, Neoplasm -
- Carcinoma in Situ - etiology
- Diagnosis, Differential - etiology
- Female - etiology
- Humans - etiology
- Immunohistochemistry - etiology
- Keratosis - metabolism
- Male - metabolism
- Melanoma - etiology
- Middle Aged - etiology
- Monophenol Monooxygenase - metabolism
- Neoplasm Proteins - metabolism
- S100 Proteins - metabolism
- Skin Neoplasms - etiology
- Sunlight - adverse effects
- Tumor Markers, Biological - analysis
- Find related publications in this database (Keywords)
- pigmented actinic keratosis
- melanoma in situ
- Melan-A