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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Jasperse, B; Valsasina, P; Neacsu, V; Knol, DL; De Stefano, N; Enzinger, C; Smith, SM; Ropele, S; Korteweg, T; Giorgio, A; Anderson, V; Polman, CH; Filippi, M; Miller, DH; Rovaris, M; Barkhof, F; Vrenken, H; Magnetic Imaging in Multiple Sclerosis (MAGNIMS) study group.
Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX.
J Magn Reson Imaging. 2007; 26(4): 881-885.
Doi: 10.1002/jmri.21101
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- Co-authors Med Uni Graz
- Enzinger Christian
- Ropele Stefan
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- Abstract:
- PURPOSE: To investigate intercenter agreement of brain volume (change) measurement in multiple sclerosis (MS) using structural image evaluation using normalization of atrophy (SIENA) and the cross-sectional version of SIENA (SIENAX) with additional manual editing to correct for inadequate brain extraction. MATERIALS AND METHODS: Baseline and follow-up T1-weighted MR images of 20 MS patients were dispatched to five centers. Each center performed fully-automated and manually-edited analyses for SIENAX, yielding normalized brain volume (NBV), and SIENA, yielding percentage brain volume change (PBVC). Intercenter agreement was assessed with the concordance correlation coefficient (CCC). RESULTS: Intercenter agreement was perfect for fully automated NBV and PBVC (both CCC = 1.0), and remained substantial upon manual editing (CCC = 0.94 for NBV, CCC = 0.95 for PBVC). Mean NBV values for each center decreased significantly after manual editing (overall mean NBV = 1605.3 cm(3) vs. 1651.1 cm(3) without manual editing; t = -4.58, P < 0.001). Total variance in PBVC decreased significantly by a factor of 1.8 after manual editing (sigma(2) = 2.82 before, and sigma(2) = 1.54 after manual editing, P < 0.05). CONCLUSION: Substantial intercenter agreement was found for manually-edited SIENAX and SIENA, suggesting that measurements from multiple centers may be pooled. Manual editing reduces overestimation of NBV, and is likely to increase statistical power for PBVC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Atrophy -
- Automation -
- Brain - metabolism
- Female - metabolism
- Humans - metabolism
- Image Processing, Computer-Assisted - methods
- Magnetic Resonance Imaging - methods
- Male - methods
- Models, Statistical - methods
- Multiple Sclerosis - pathology
- Pattern Recognition, Automated - pathology
- Reproducibility of Results - pathology
- Find related publications in this database (Keywords)
- MRI
- brain volume
- multiple sclerosis
- multicenter
- agreement