Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Baranyi, A; Yazdani, R; Haas-Krammer, A; Stepan, A; Kapfhammer, HP; Rothenhäusler, HB.
Atypical antipsychotics and metabolic syndrome
Wien Med Wochenschr. 2007; 157(11-12): 255-270.
Doi: 10.1007/s10354-007-0379-9
PubMed
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- Leading authors Med Uni Graz
- Baranyi Andreas
- Co-authors Med Uni Graz
- Kapfhammer Hans-Peter
- Krammer Alexandra
- Rothenhäusler Hans-Bernd
- Stepan Alexandra
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- Abstract:
- The introduction of atypical antipsychotics in psychopharmacology represented a major advance in the treatment of psychotic disorders. However, there have been numerous studies that certain atypical antipsychotics may be associated with a greater risk of metabolic abnormalities than others, including weight gain, hyperlipidemia and new-onset typ 2 diabetes mellitus. A G-Protein beta3 subunit Gen (C825T) polymorphism, an increased carbohydrate metabolism and dyshormonism are discussed as pathogenetic mechanisms. High risk patients (adiposity, hyperlipidaemia, hyperglycaemia, preexisting diabetes) should maintain an antipsychotic agent with a favourable side effect profile. In these cases a periodical diabetes screening and blood lipid controls are required. Clinicans must balance the significant benefits of atypical antipsychotics against the risk of metabolic disturbances. In this article recent findings are reviewed.
- Find related publications in this database (using NLM MeSH Indexing)
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