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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Karakiewicz, PI; Hutterer, GC; Trinh, QD; Jeldres, C; Perrotte, P; Gallina, A; Tostain, J; Patard, JJ.
C-reactive protein is an informative predictor of renal cell carcinoma-specific mortality: a European study of 313 patients.
Cancer. 2007; 110(6):1241-1247
Doi: 10.1002/cncr.22896
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- Co-authors Med Uni Graz
- Hutterer Georg
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- Abstract:
- BACKGROUND: C-reactive protein (CRP) represents a promising prognostic variable in patients with sporadic renal cell carcinoma (RCC). It was hypothesized that CRP can improve the prognostic ability of standard RCC-specific mortality (RCC-SM) predictors in patients treated with nephrectomy for all stages of RCC. METHODS: Radical nephrectomy was performed in 314 patients from 2 European centers. Life table, Kaplan-Meier, and Cox regression analyses addressed RCC-SM. Covariates included age, gender, TNM stage, tumor size, Fuhrman grade, and histologic subtype. RESULTS: The median survival of the cohort was 19.9 years. Age ranged from 10 to 77 years. Most patients were male (69%). T-stages were distributed as follows: T1-121 (38.7%), T2-45 (14.4%), T3-140 (44.7%), T4-7 (2.2%). CRP values ranged from 1.0 to 358.0 mg/L (mean 40.9, median 11.0 mg/L). In multivariable analyses, CRP was an independent predictor of RCC-SM (P = .003). The consideration of CRP in the multivariable model increased the predictive accuracy by 3.7% (P < .001). Moreover, the model with CRP performed 2.4% and 4.6% better than the UCLA Integrated Staging System (UISS) at, respectively, 2 and 5 years. CONCLUSIONS: CRP represents an informative predictor of RCC-SM. Its routine use could allow better risk stratification and risk-adjusted follow-up of RCC patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- C-Reactive Protein - metabolism
- Carcinoma, Renal Cell - blood
- Child - blood
- Europe - epidemiology
- Female - epidemiology
- Humans - epidemiology
- Kidney Neoplasms - blood
- Male - blood
- Middle Aged - blood
- Multivariate Analysis - blood
- Predictive Value of Tests - blood
- Prognosis - blood
- Prospective Studies - blood
- Retrospective Studies - blood
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- c-reactive protein
- mortality
- prognosis
- renal cell carcinoma