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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hutterer, GC; Patard, JJ; Jeldres, C; Perrotte, P; de La Taille, A; Salomon, L; Verhoest, G; Tostain, J; Cindolo, L; Ficarra, V; Artibani, W; Schips, L; Zigeuner, R; Mulders, PF; Karakiewicz, PI.
Patients with distant metastases from renal cell carcinoma can be accurately identified: external validation of a new nomogram.
BJU Int. 2008; 101(1): 39-43.
Doi: 10.1111/j.1464-410X.2007.07170.x
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- Leading authors Med Uni Graz
- Hutterer Georg
- Co-authors Med Uni Graz
- Zigeuner Richard
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- Abstract:
- OBJECTIVE: To identify clinical variables that can accurately predict the presence of distant metastases in patients with renal cell carcinoma (RCC). PATIENTS AND METHODS: Age, symptom classification, tumour size and the prevalence of distant metastases at diagnosis before nephrectomy were available for 5376 patients with pathologically confirmed RCC. The data of 2660 (49.5%) patients from 11 centres were used to develop a multivariable logistic regression model-based nomogram predicting the individual probability of distant metastases. The remaining data from 2716 (50.5%) patients from three institutions were used for external validation. RESULTS: In the development cohort, 269/2660 (10.1%) had distant metastases, vs 285/2716 (10.5%) in the external validation cohort. Symptom classification and tumour size were independent predictors of distant metastases in the development cohort; age was not an independent predictor. A nomogram based on symptom classification and tumour size was 85.2% accurate in predicting the individual probability of distant metastases in the external validation cohort. CONCLUSION: Although distant metastases might be easily identifiable in some patients, their diagnosis might be a challenge in others. The current nomogram provides a simple, user-friendly and, most importantly, an accurate tool aimed at predicting the probability of distant metastases in patients with RCC.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Renal Cell - pathology
- Cohort Studies -
- Humans -
- Kidney Neoplasms - pathology
- Lymphatic Metastasis -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Staging -
- Nephrectomy -
- Nomograms -
- Retrospective Studies -
- Risk Factors -
- Find related publications in this database (Keywords)
- lymph node metastases
- renal cell carcinoma
- stage
- symptom classification