Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Estelberger, W; Weiss, G; Petek, W; Paletta, B; Wachter, H; Reibnegger, G.
Determination of renal clearance of neopterin by a pharmacokinetic approach.
FEBS Lett. 1993; 329(1-2):13-16
Doi: 10.1016/0014-5793(93)80182-T
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- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
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- Abstract:
- Pharmacokinetic modelling was used to determine the glomerular filtration rate and tubular secretion of neopterin, a marker for cellular immune activation. The method involves parameter identification employing the transient venous plasma concentration profiles of marker substances. By combined i.v. injection of neopterin and inulin which is excreted exclusively via glomerular filtration, neopterin was shown to be excreted in addition to glomerular filtration, by tubular secretion: clearance of inulin, 112 (S.D. 2.2) ml/liter; clearance of neopterin, 499 (S.D. 79.7) ml/min. A pilot experiment using in addition p-amino hippuric acid suggests that neopterin and p-amino hippuric acid may employ the same carrier system for tubular secretion.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Biopterin - analogs and derivatives
- Glomerular Filtration Rate - analogs and derivatives
- Humans - analogs and derivatives
- Inulin - pharmacokinetics
- Kidney - metabolism
- Kidney Tubules - secretion
- Kinetics - secretion
- Male - secretion
- Mathematics - secretion
- Metabolic Clearance Rate - secretion
- Models, Biological - secretion
- Neopterin - secretion
- p-Aminohippuric Acid - pharmacokinetics
- Find related publications in this database (Keywords)
- Neopterin
- Renal Clearance
- Glomerular Filtration
- Tubular Secretion
- Pharmacokinetics
- Mathematical Modeling