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Selected Publication:
Jansen, J; Gres, P; Umschlag, C; Heinzel, FR; Degenhardt, H; Schluter, KD; Heusch, G; Schulz, R.
Parathyroid hormone-related peptide improves contractile function of stunned myocardium in rats and pigs.
Am J Physiol Heart Circ Physiol. 2003; 284(1):H49-H55
Doi: 10.1152/ajpheart.01037.2001
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- Co-authors Med Uni Graz
- Heinzel Frank
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- Abstract:
- The effect of synthetic parathyroid hormone (PTH)-related peptide [PTHrP(1-34)] on regional myocardial function was studied in 11 anesthetized pigs. Intracoronary infusion of PTHrP (cumulative dose: 14 +/- 1 microg) decreased coronary resistance to 33 +/- 2% of baseline (P < 0.05) and regional myocardial function to 90 +/- 3% of baseline (not significant). Ischemia-reperfusion alters the activity of several kinases and therefore possibly the myocardial effects of PTHrP. In stunned myocardium, induced by 20-min ischemia and 30-min reperfusion, the dose of PTHrP reducing coronary resistance to a minimum of 29 +/- 2% was decreased to 8 +/- 2 microg (P < 0.05). Regional myocardial function was no longer decreased but increased to 132 +/- 9% (P < 0.05). The increase in regional myocardial function during PTHrP was inversely related to baseline function at 30-min reperfusion in vivo (r = 0.9) as well as in myocytes isolated from stunned pig hearts (r = 0.7). In isolated rat hearts subjected to 30-min global ischemia followed by 30-min reperfusion, blockade of endogenous PTHrP by d-Trp(12)-Tyr(34)-PTH(7-34) attenuated the recovery of left ventricular developed pressure by 30 +/- 14% (P < 0.05). Thus endogenous and exogenous PTHrP impact on the function of stunned myocardium.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Coronary Circulation - drug effects
- Heart - drug effects
- Hemodynamic Processes - drug effects
- Myocardial Contraction - drug effects
- Myocardial Stunning - drug effects
- Myocardium - metabolism
- Myocytes, Cardiac - drug effects
- Oxygen Consumption - drug effects
- Parathyroid Hormone - pharmacology
- Parathyroid Hormone-Related Protein - pharmacology
- Peptide Fragments - pharmacology
- Peptide Hormones - physiology
- Rats - physiology
- Rats, Wistar - physiology
- Swine - physiology
- Swine, Miniature - physiology
- Vascular Resistance - drug effects
- Ventricular Function - drug effects
- Find related publications in this database (Keywords)
- ischemia
- reperfusion
- coronary blood flow
- hormones
- inotropy